The train station at which Stephen Reinhart (Nick Adams) disembarks is called Arkham. Arkham was a fictional town created by H.P. Lovecraft.

The film was not actually shot in widescreen. It was converted to CinemaScope in the final print after having been shot in standard Academy ratio, much like some films which are "matted" after having been shot in Academy ratio. The process used was contemporary of Superscope and a forerunner of Super 35. It was filmed using spherical lenses at an aspect ratio of 1.37:1. In the printing process, the images were cropped to a height of 2 perforations giving them an aspect ratio of 2.36:1. The images were then stretched vertically to a height of 4 perforations, at which point they conformed to the standard CinemaScope-2 format.

Directorial debut of Daniel Haller.

In 1965 American International Pictures distributed this film on a double bill with the Italian sci-fi film Planet of the Vampires (1965), which was dubbed in English and retitled "Planet of the Vampires".

"The Monster in the House at the End of the World" served as working title,

The central premise is reminiscent of that of a film that Karlofff made three decades earlier. In The Invisible Ray (Universal 1936) Karloff plays a scientist who is experimenting with a radioactive meteor which causes him to glow dangerously and ultimately burn to ashes.