Genocide was co-written by Susumu Takaku, an anime and live-action screenwriter. The films staff includes Shizuo Hirase as the cinematographer who also worked on the Shochiku films The X from Outer Space and Goke, Body Snatcher from Hell.
Genocide was released in Japan on 9 November 1968. It was released as a double feature with The Living Skeleton. The film was released in the United States by Shochiku Films of America in 1969. The film was promoted under the title War of the Insects on this release.
The Criterion Collection released Genocide on DVD in a compilation set titled When Horror Came to Shochiku through their Eclipse label. The box set was released on November 20, 2012.