This was the first in the "Dexter Riley" movies, a trilogy of three high-concept Disney fantasy-comedies starring Kurt Russell as Dexter, with Joe Flynn and Cesar Romero. These films were set in Medfield College where a scientific breakthrough would lead to hijinks. They were The Computer Wore Tennis Shoes (1969) (robotics / human computers), Now You See Him, Now You Don't (1972) (invisibility) and The Strongest Man in the World (1975) (super-strength).

The "campus" shown outside the window of the Dean's office is actually a photograph of buildings in the Walt Disney Studios. This very same backdrop was used during the run of the "Disneyland" television show for scenes shot on the set that served as Walt Disney's "office" when he hosted segments of the program. One oddity is that the building seen in the backdrop was actually the one that housed the real location of Walt's office.

The name of the educational institution was "Medfield College". The campus setting also featured in other Disney films such as this movie's sequels Now You See Him, Now You Don't (1972) and The Strongest Man in the World (1975) as well as the earlier The Absent Minded Professor (1961) and its sequel Son of Flubber (1963).

The glimpse of Disney Studios goes well beyond the use of a backdrop. The exterior college shots (excluding the opening still frame of a specific building) are of the Disney Studio campus. Walt Disney intended for the studio to have such a look. The early scene where the students eavesdrop on the meeting of school officials takes place on the patio of the studio commissary.

When Dexter takes the computer part back, he has bits of paper all over the side window of his car. When he gets there his car has no side windows.

Sight gag: When A.J. Arno opens his secret door, his copy of the famous painting Whistler's Mother splits in two along with the door. But as Whistler's mother slides to the left, the chair she was sitting on, which cannot be seen in the original painting, appears in full from underneath her.

This movie was remade in 1995 for television: The Computer Wore Tennis Shoes (1995).

The picture was the "first of Disney's carbon-copy comedies" according to film critic Leonard Maltin.

Uncredited debut cinema movie of actor Ed Begley Jr..

Some of the colleges that faced off against the Medfield Lions on the television quiz show "Universal Encyclopaedia" were Paterson College, Franklin University, the Springfield State Rockets, and the Rockhurst Bulldogs, which were also referred to as the Lockhurst Bulldogs.

The picture was made as part of the Walt Disney and Buena Film Distribution Companys' series of "The Last Laughs of the 1960s".

The slogan of the Medfield Paint Company was "We Cover The County".

The TV College Bowl game show quiz tournament prize money was 100,000 dollars.

The name of the television station was "WCBD-TV".

The word that triggered Dexter's memory during the game show was "applejack".

First of two live-action films by Disney to feature Frank Welker, known primarily as a voice actor, in an on-camera role.

According to "Variety" this movie was Robert Butler's "debut swing to pix from telefilm", although in the same year Butler directed Guns in the Heather (1969), which was made-for-television, but was re-edited into feature film form for European theatrical release.

The amount of money that A.J. Arno (Cesar Romero) annually donated to Medfield College was 20,000 dollars.

Debut produced screenplay of Assistant Director and Screenwriter Joseph L. McEveety.

The nickname of Lieutenant Charles Hannah (Peter Renaday) was "Charlie".