While the film shows a bus skidding into a high tension tower, the newspaper article about Dan McCormick leaving the hospital states it was an accident with an interurban car and an oil truck.

"Man-Made Monster" launched Lon Chaney Jr.'s career as a star in horror films and the film's success directly led to his casting in the big budget role of his career, "The Wolf Man."

Budgeted at a mere $86,000 on a 3-week shooting schedule. It was the cheapest feature film produced by Universal in 1941.

Based on the story, "The Electric Man" which Universal had purchased for $3,300 in 1935 as a potential Boris Karloff / Bela Lugosi vehicle to be titled "The Man in the Cab." The studio, in the midst of a financial debacle at the time, shelved the project for over five years, assigning the re-write to George Waggner (working as "Joseph West") who re-tooled it as "The Human Robot."

Byron Foulger's role as '2nd Alienist' was cut prior to release, reducing the film's running time to under an hour, but still receives on screen billing.

Shooting began December 9, 1940, released March 19, 1941.

Two of the film's stars - Frank Albertson and Samuel Hinds appeared together in "It's a Wonderful Life." as Sam Wainwright and Pa Bailey.

Part of the original Shock Theater package of 52 Universal titles released to television in 1957, followed a year later with Son of Shock, which added 20 more features.

The rubber suit worn by Chaney weighed 70 pounds.

Though he did not get screen credit, Hans J. Salter's music for this film, specifically the repetitive percussion and strings theme heard when Lon Chaney's character is roaming the countryside wreaking havoc, was recycled in several other low budget Universal horror films of the 1940s, among them sequels featuring Frankenstein's monster, the mummy and the wolfman.

Dan McCormick (Lon Chaney Jr.) kills Dr. Paul Rigas (Lionel Atwill) with a jolt of electricity. In The Ghost of Frankenstein (1942) The Monster (Lon Chaney Jr.) kills Dr. Bohmer (Lionel Atwill) by pushing him into a control box electrocuting him.

Lionel Atwill plays a mad scientist here and in The Ghost of Frankenstein (1942). In both films Lon Chaney Jr. plays the monster and kills each of Atwill's respective characters the same way, with electricity. The one other title featuring Atwill as a mad scientist was the 1942 release "The Mad Doctor of Market Street."