Godzilla's famous/infamous "victory dance" after defeating King Ghidorah on Planet X was based upon the "shê" gag pose, a trademark of the mischievous character Iyami from the manga "Osomatsu-kun," created by famous Japanese cartoonist Fujio Akatsuka. Iyami would go into this pose every time he is surprised, and scream "shê!" This has become a famous pose in Japanese popular culture. Yoshio Tsuchiya (the actor playing the Controller of Planet X) was a big fan of the "Osomatsu-kun" comic-strip, and asked special effects director Eiji Tsuburaya if Godzilla could do a "shê" pose. Having already given Godzilla a more humorous and playful side, Eiji agreed, cleverly incorporating the pose into a "victory dance" for the monster. However, director Ishirô Honda was not impressed. After some debating, it was ultimately left in the final print.

Mothra was slated to appear in this film, but for budgetary reasons, she was dropped from the film, as were all references to her in the original script.

Nick Adams is speaking English throughout the Film, despite the fact he seems to be conversing with the other actors, who are clearly speaking Japanese. Adams was simply dubbed over into Japanese for the Japanese release. Conversely, when the film was finally released in the US, Nick Adams voice is the only voice not dubbed over. The Japanese speaking actors are dubbed over into English.

The effect of the water seemingly exploding when the flying saucers emerge from the lake was achieved by filling a thermos full of carbon dioxide and exploding it underwater.

Godzilla's design was tweaked again after San daikaijû: Chikyû saidai no kessen (1964). This design made Godzilla look less menacing and more friendly. The head was shorter and more round, the eyes were larger and more movable, the dorsal fins were a little smaller, and the tongue was much larger. In addition, the suit was made wider under the arms to allow more movement for the actor. However, the effect made the costume appear too "baggy."

The design of the P-1, especially the nose cone, was based on the rockets used for the Gemini space program, which had just started as filming for this picture commenced.

The new Godzilla suit made for this film, called the "Daisenso-Goji," possessed a somewhat friendlier look than the more menacing previous suit, the "Mosu-Goji" (first used in Mosura tai Gojira (1964)), considering that the previous film, San daikaijû: Chikyû saidai no kessen (1964), was the beginning of Godzilla's "hero" status (albeit still a reluctant antihero). This suit would "star" in only one more Godzilla film, 1966's Ebirah, Terror of the Deep (1966), during filming of which Tsuburaya Productions took the head of the suit and fastened it to the body of the Mosu-Goji suit for use as the monster Jirass in the TV show Urutoraman: Kûsô tokusatsu shirîzu (1966). In that event, a new head had to be made for the headless Daisenso-Goji suit in short order, creating a strangely bug-eyed stare with an elevated eyebrow line (thus becoming the "Nankai-Goji"). Since then, the Nankai-Goji suit would be a stunt/water suit for all subsequent Godzilla films up to its final appearance in Gojira tai Hedora (1971) in 1971. (In that film, apart from the water scenes, this suit was used for the scene where Godzilla was being covered in sludge by the monster Hedorah.)

After the enormous success of the U.S. release of San daikaijû: Chikyû saidai no kessen (1964), some publications ran articles and photographs of this sequel as an upcomeing release under the title "Invasion of Astro-Monster". However, this film was not released in the U.S. until the summer of 1970 under the title "Monster Zero".

When this film was released in the US in 1970, it was released on a double bill with Furankenshutain no kaijû: Sanda tai Gaira (1966). That film was a sequel to Furankenshutain tai chitei kaijû Baragon (1965) which stared Adams. Originally, Adams was signed to that film too, however, Russ Tamblyn was eventually cast in his place after his death.

In the scene where Glenn and Fuji meet with the Planet X Controller, Glenn refers to Rodan and King Ghidorah by their Japanese names, Radon and Kingughidorah.

This film wasn't released in the US for five years, perhaps because of the death of star Nick Adams. Another possibility is that producer Henry G. Saperstein, who picked up the US distribution rights, had had a falling out with his previous business partners, Samuel Z. Arkoff and James H. Nicholson of American-International Pictures. Eventually, Maron Films distributed the film in the US.

For some close-ups of Godzilla's foot stomping on houses, a 1/10 scale model on a metal rod was used. Although there are several shots of this in the final cut, the prop was a bit of a head-ache for the effects crew. On the Japanese DVD of this film, there is blooper footage of the foot coming loose and bouncing away several times.

In Germany, this movie was released under the title "Befehl aus dem Dunkel" ("Order out of the Dark"), originally the title of a SciFi novel by German author Hans Dominik, published in 1933. Although the movie's plot has nothing in common with this book (which prefigures the political effects of a mind reading device), it was even billed as "based on Hans Dominik" and the author's (who had died in 1945) name was widely used in promotion.

After its initial U.S. showings, the film was advertised in some venues under the title "Invasion of the Astros," although the actual prints used still carried the "Monster Zero" title.

Japan Import DVD has Super-8mm version (Japanese Audio), as a special feature.

Gregg's reactions to adversity visit are limited to the unbuttoning of his jacket, tugging up his belt, then placing his hands on his hips. He does this at least four times during the early part of the movie,

This marked the first of three series appearances for Akira Kubo.