One of the first films to use squibs to simulate gunshot wounds

Columbia booked this across the United States as a standard double bill with It Came from Beneath the Sea (1955)

The film uses the old Columbia Ranch back lot in Burbank, now named the Warner Brothers Ranch, extensively filming on its residential and city street sets. The shot showing the "Monroe Air Force Base" utilized the ranch's entrance with its two gate houses.

To keep the budget low, like many directors of the period, Edward L. Cahn chose to shoot the film with in as few breaks and edits as feasible, so that the characters are constantly standing, sitting, and pacing to avoid the tedium of talking-head shots. Even when characters move from room to room, there are very few cuts. The effect is both impressive and amusing, once the viewer becomes aware of it, and could inspire a Drinking Game based on spotting the edits!

Creature with the Atom Brain inspired the name of the Belgian rock band Creature with the Atom Brain, as well as the 1980 Roky Erickson & The Aliens song of the same name.

Director Cahn would go on to make Invisible Invaders (1959) using the same basic concept (in the later film, invading aliens inhabit the reanimated corpses of humans).

Sony Pictures Home Entertainment released the film on DVD in October 2007 as part of the two-disc, four-film set Icons of Horror Collection: Sam Katzman, along with three other films produced by Katzman (The Werewolf, The Giant Claw and Zombies of Mora Tau).